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The Screen shot has (click to see) some requirement written on it. In addition, here are some direction.
*The Top bar (including the Featured Posts), Footer and the Side bar (300 pixels) will be constant on all pages.
*Category Page, Video MainPage, Photos mainpage, search result page, Tag content page will be Setup Like this: http://mashable.com/tag/google/
*Author Page setup: http://mashable.com/author/adam-ostrow/