This report is aimed at the effects of mood disorders on worker job functional abilities. A literature search needs to be conducted of of meta-analysis and COCHRANE literature on the impairing effects of Depression and Anxiety Mood Disorders. The focus will be on objective evidence (clinical signs, biomarkers, neurocognitive testing) versus subjective symptoms. Literature based solely on self report questionnaires and symptom checklists is to be excluded.
The report needs to document and develop medical decision-making algorithms regarding the link between diagnostic severity and neurocognitive impairments (memory, attention, executive functions, psychomotor-visuospatial abilities) and identify any correlated pathophysiological biomarkers. Additionally the report needs to demonstrate how a clinician can discriminate cognitive impairment due to mood disorder versus co-existing or developing dementia. The report needs to assist the reader with an understanding of the correlation between diagnostic severity, biomarkers and impairment levels, so the literature on impairment needs to be reported within Standard Deviations, percentiles distilled from the literature.
Additionally the literature needs to research on impairment of social skills and coping abilities and correlate it to work stress with the job stress-strain model.
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