We did study of Haemostatic Factors (ONLY) as Biomarkers of Significant Liver Fibrosis in Patients with Chronic Hepatitis C ( see attached manuscript) . We found it a negative study and challenged to be published. So we did reanalysis and included the results of fibroscn and other noninvasive score APRI, FIB-4 AND AST/ALT ratio and we want rewrite it after combining all these markers and score.
Importance: most of the studies in hematologic factors in liver disease did not assess liver fibrosis in large biopsy study….most studies for hematology assess this in cirrhotic ( but not patient with less degree of fibrosis)
To assess the performance of selected natural anticoagulants suing liver biopsy as the gold standard.
Compare performance of natural anticoagulants with traditional noninvasive methods
What is needed:
To write the manuscript with new objective and including noninvasive scores and fibroscan in addition to the hemostatic factors
Rearrange and include tables
Update and included relevant references
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