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Project LITERATURE REVIEW - Histology/ Immunohistochemistry

The following piece of written essay work CRITICAL LITERATURE REVIEW (carried out on MS WORD - max 2500 words) on the following topic below:


Projects in this area will look at exploiting the use of immunohistochemistry and novel antibody biomarkers to improve diagnosis of malignant conditions. You will need to demonstrate an understanding of the technology involved and how you might use this in a project consider one of the below;

Compare and contrast the use of traditional prostate markers (e.g. Cytokeratins) with novel antibodies such as p63, Pin4 and ERG in the diagnosis and grading of prostate carcinoma.

Compare and contrast the use of traditional single markers (e.g S100, Melan A, HMB45) with antibody cocktails in the diagnosis and grading of malignant melanoma.

Suggested Reading

Search the theory behind Immunohistochemistry, necessity for antigen retrieval, choice of chromogen and method of automation available (especially concentrate on Dako Autostainer and Menarini Intellipath)

Read about antibodies available as mentioned above and advantages and disadvantages of each.

If you have experience in a medical/biology backgound then this will be sufficient! The budget is suffiently calculated since this is an essay! YOU MUST ENSURE THAT THE ESSAY IS IN THE FORM OF A CRITICAL LITERATURE REVIEW ONLY! IT MUST ONLY BE RELAVENT TO THE ABOVE BACKGROUND TOPICS!

Any plagerism will be detected using special software and is a serious offence, this will be reported to the authorities! Only GENUINE writers only!!! Thanks


The following essay needs to meet these requirements::

Analyse the topic –

read the textbooks as background before moving to the published articles. Use the bad science and info trawl worksheets to help with this.

What exactly are you being asked to do? –

Define a research question in the area of research determined by your supervisor.

Locate appropriate published research on the topic –

Review the information from Elaine Newell to help with this

You will need to read extensively to complete this

Be very careful about using material you have located on the Internet!

Read and understand the research you have located –

Go back to the textbooks if necessary to decipher the jargon in the scientific articles

Summarise the research

Analyse the research –

Not in a paper by paper fashion but as a whole.

What methods have been used?

What findings have been reported?

What common strands are there?

What differences are there?

What are the strengths and weaknesses of the research?

How convincing is the research?

What further research may be needed?

Decide on an organisation for your analysis. For example:

General to specific

Chronological (oldest to most recent)



Define your question

Skills: Biology, Medical, Research Writing, Scientific Research, Technical Writing

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About the Employer:
( 53 reviews ) London, United Kingdom

Project ID: #1289197

10 freelancers are bidding on average $59 for this job


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