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$38 USD / hour
Flag of UNITED STATES
carrboro, united states
$38 USD / hour
It's currently 7:46 PM here
Joined November 20, 2017
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Brian B.

@BDBLLC

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$38 USD / hour
Flag of UNITED STATES
carrboro, united states
$38 USD / hour
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Molecular Biologist, Research Scientist

Brian Bower and his company, BDB LLC, has been helping meet the scientific and technical consulting and contracting needs of clients in/around the Raleigh-Durham-Chapel hill and Research Triangle Park (RTP) areas of North Carolina since 2017. While the primary focus of BDB LLC is molecular biology, some additional capabilities related to the below skills are available: -Writing and editing -HTML/CSS/PHP -Java -C# -Python
Freelancer Data Entry Clerks United States

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Experience

Founder and CEO

Brian David Bower LLC
Jul 2017 - Present
• Company formed to offer Brian David Bower’s labor on a contingent or contract basis. • Established a vendor relationship with clients throughout North Carolina. • Provided scientific solutions, consulting and contracting to the RTP area. • Established groundwork for ongoing private independent research and development projects

Research Scientist

Chaperone Therapeutics, Inc.
Mar 2018 - Aug 2020 (2 years, 5 months)
• Worked on contract for Chaperone Therapeutics, Inc. through BDB LLC. • Set up and operated Chaperone Therepeutic, Inc.’s lab in the BioLabs North Carolina Incubator. • Facilitated acquisition and setup of a LI-COR Odyssey CLx Imaging System. • Conceived of, developed, validated and employed cell-culture and multiplex-western blot compound screening assays.

Regulatory Protein Biochemist / Technical Consultant

BASF Corporation
Jan 2017 - Feb 2018 (1 year, 1 month)
• Worked on contract for BASF while employed by Synectics Inc. • Validated assays to detect and quantify transgenic protein expression in plants, plant tissues and plant derived products (via Protein Simple Wes), to support product development & deregulation. • Worked in accordance with Environmental Protection Agency (EPA) Good Laboratory Practices (GLPs) in a fast-paced environment.

Education

Graduate Certificate in Bioinformatics and Computational Biology

University of North Carolina at Chapel Hill, United States 2009 - 2014
(5 years)

PhD, Genetics and Molecular Biology

University of North Carolina at Chapel Hill, United States 2009 - 2014
(5 years)

History Minor

Ohio University, United States 2009
(Less than a year)

Qualifications

Graduate Certificate in Bioinformatics and Computational Biology

UNC Curriculum in Bioinformatics & Computational Biology
2014
A certification of completion of non-degree-conferring course of study on topics related to Bioinformatics and Computational Biology conferred by the UNC Curriculum in Bioinformatics & Computational Biology.

Publications

17-α ESTRADIOL AMELIORATES AGE-ASSOCIATED SARCOPENIA AND IMPROVES LATE LIFE PHYSICAL FUNCTION IN...

publication description Aging Cell
Michael Garratt, Danielle Leander, Kaitlyn Pifer, Brian Bower, Jonathan J. Herrera, Sharlene M. Day, Oliver Fiehn, Susan V. Brooks, Richard A. Miller Aging Cell. 2019 Apr; 18(2): e12920. Published online 2019 Feb 10. doi: 10.1111/acel.12920 PMCID: PMC6413653 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413653/)

The use of proteomics to study infectious diseases

Infectious Disorders and Drug Targets
Infect Disord Drug Targets. 2008 Mar;8(1):31-45. The use of proteomics to study infectious diseases. List EO, Berryman DE, Bower B, Sackmann-Sala L, Gosney E, Ding J, Okada S, Kopchick JJ. (https://www.ncbi.nlm.nih.gov/pubmed/18473905)

Laron Syndrome – From Man to Mouse (Cancer Chapter)

Springer - Verlag GmbH
Kopchick, JJ and Bower, B. (2011). Cancer. In: Laron, Z and Kopchick, JJ. Laron Syndrome – From Man to Mouse. Heildelberg: Springer - Verlag GmbH Berlin. 495-505. Despite discrepancies both within and between data from human patient populations and mouse models of altered GH induced signaling, abrogation of this signaling via mutation of the GHR appears to protect both mice and humans from cancer development and progression... (https://link.springer.com/chapter/10.1007/978-3-642-11183-9_57)

Growth hormone improves body composition, fasting blood glucose, glucose tolerance and liver...

Diabetologia
Diabetologia. 2009 Aug;52(8):1647-55. doi: 10.1007/s00125-009-1402-z. Epub 2009 May 26. Growth hormone improves body composition, fasting blood glucose, glucose tolerance and liver triacylglycerol in a mouse model of diet-induced obesity and type 2 diabetes. List EO, Palmer AJ, Berryman DE, Bower B, Kelder B, Kopchick JJ. (https://www.ncbi.nlm.nih.gov/pubmed/19468705)

Differential effects of growth hormone versus insulin - like growth factor - I on the mouse...

Endocrinology
Endocrinology. 2011 Oct;152(10):3791-802. doi: 10.1210/en.2011-1217. Epub 2011 Jul 26. Differential effects of growth hormone versus insulin-like growth factor-I on the mouse plasma proteome. Ding J, List EO, Bower BD, Kopchick JJ. (https://www.ncbi.nlm.nih.gov/pubmed/21791560)

Biophysical and ultrastructural characterization of adeno - associated virus capsid uncoating...

Journal of Virology (J Virol)
J Virol. 2013 Mar;87(6):2994-3002. doi: 10.1128/JVI.03017-12. Epub 2012 Dec 26. Biophysical and ultrastructural characterization of adeno-associated virus capsid uncoating and genome release. Horowitz ED, Rahman KS, Bower BD, Dismuke DJ, Falvo MR, Griffith JD, Harvey SC, Asokan A. (https://www.ncbi.nlm.nih.gov/pubmed/23269804) Cover features electron micrographs I collected (http://jvi.asm.org/content/87/18.cover-expansion)

A guanosine - centric mechanism for RNA chaperone function.

Science
Science. 2013 Apr 12;340(6129):190-5. doi: 10.1126/science.1230715. Epub 2013 Mar 7. A guanosine-centric mechanism for RNA chaperone function. Grohman JK, Gorelick RJ, Lickwar CR, Lieb JD, Bower BD, Znosko BM, Weeks KM. (https://www.ncbi.nlm.nih.gov/pubmed/23470731)

TRF1 and TRF2 differentially modulate Rad51 - mediated telomeric and nontelomeric displacement...

Biochemistry (ACS)
Biochemistry. 2014 Sep 2;53(34):5485-95. doi: 10.1021/bi5006249. Epub 2014 Aug 21. TRF1 and TRF2 differentially modulate Rad51-mediated telomeric and nontelomeric displacement loop formation in vitro. Bower BD, Griffith JD. (https://www.ncbi.nlm.nih.gov/pubmed/25115914)

Sex differences in lifespan extension with acarbose and 17 - α estradiol: gonadal hormones...

Aging Cell
Aging Cell. 2017 Dec;16(6):1256-1266. doi: 10.1111/acel.12656. Epub 2017 Aug 22. Sex differences in lifespan extension with acarbose and 17-α estradiol: gonadal hormones underlie male-specific improvements in glucose tolerance and mTORC2 signaling. Garratt M, Bower B, Garcia GG, Miller RA. (https://www.ncbi.nlm.nih.gov/pubmed/28834262)

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