Torin H. Profile

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$50 USD / hour

waterdown,

canada

$50 USD / hour

It's currently 8:28 PM here

Joined August 17, 2009

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Torin H.

@thuzil

0.0

(0 reviews)

0.0

$50 USD / hour

waterdown,

canada

$50 USD / hour

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Biotechnology

I am an academic researcher and freelancers specializing in biochemistry with specific expertise in protein modeling drug design and drug delivery. I have extensive experience in manuscript and grant preparation and copy editing.

See all Electronics Engineers in Canada

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Portfolio

Binding interaction of Ubiqutin and the Ubiquitin conjugating enzyme UBC1 as determined by NMR spectrosopy and computational docking.

UBC1 Ubiquitin binding

294826

A Unique Mode of Microtubule Stabilization

Reconstruction of a single microtubule layer. Reproduced from electron microscopy data and the coordinates for the tubulin dimer.

Microtubule reconstruction

Image of the chemotherapy agent colchicine bound to beta-tubulin

Colchicine Binding to Tubulin

UBC1 Ubiquitin binding

294826

A Unique Mode of Microtubule Stabilization

Microtubule reconstruction

Colchicine Binding to Tubulin

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Experience

University of Guelph

Sep 2012 - Present

Coordinator for 4th year medical toxicology in the department of Biomedical Sciences.

University of Waterloo

Dec 2009 - Oct 2012 (2 years, 10 months)

Developed a platform consisting of computational modeling and experimental microcalorimetry of lipid vesicles. Using molecular dynamics simulations, I modeled the free energy associated with membrane disruption by several solvents and detergents. The examination of identical membrane systems using isothermal titration microcalorimetry experiments provided correlation with thermodynamic parameters obtained from computational results.

University of Alberta

Jan 2005 - Oct 2008 (3 years, 9 months)

Virtual drug screening, protein modeling, drug design, grant development and writing

Education

PhD in Biochemistry

Canada

1997 - 2004

(7 years)

BsC in Chemistry

Canada

1990 - 1995

(5 years)

Qualifications

American Chemical Society

2004

ACS guidelines require that approved programs offer and certified majors graduate with the equivalent of three semester hours of biochemistry. Molecular aspects of biological structures, equilibria, energetics, and reactions should be covered in the required biochemistry experience for chemistry majors. Sufficient introduction to these topics should be presented so that students can obtain the flavor of modern biochemistry.

Publications

A unique mode of microtubule stabilization induced by peloruside A

J Mol Biol

Huzil J.T., Chik J.K., Slysz G.W., Freedman H., Tuszynski J., Taylor R.E., Sackett D.L., and Schriemer D.C. A unique mode of microtubule stabilization induced by peloruside A. J Mol Biol. 378:1016-30. (2008).

Contributions to Colchicine Binding within Tubulin Isotypes

Electromagnetic Biology and Medicine

Huzil J.T., Barakat K. and Tuszynski J.A., Electrostatic Contributions to Colchicine Binding within Tubulin Isotypes, Electromagnetic Biology and Medicine. 28:355-364. (2009)

Computer Assisted Design of Second-Generation Colchicine Derivatives

Interdiscip Sci Comput Life Sci

Huzil J.T., Mane J. and Tuszynski J.A., Computer Assisted Design of Second-Generation Colchicine Derivatives, Interdiscip Sci Comput Life Sci 2:169-174. (2010).

Computational Design and Biological Testing of Highly Cytotoxic Colchicine Ring A Modifications

Chemical Biology & Drug Design

Huzil J.T., Winter P., Johnson J., Weis A.L., Bakos T., Banerjee A., Luduena R.F., Damaraju S. and Tuszynski J.A. Computational Design and Biological Testing of Highly Cytotoxic Colchicine Ring A Modifications, Chemical Biology & Drug Design. 75:541-550. (2010).

Drug delivery through the skin: molecular simulations of barrier lipids to design more effective noninvasive dermal and transdermal delivery systems for small molecules, biologics, and cosmetics

WIREs Nanomedicine and Nanobiotechnology

Huzil J.T., Sivaloganathan S., Kohandel M. and Foldvari M. Drug delivery through the skin: molecular simulations of barrier lipids to design more effective noninvasive dermal and transdermal delivery systems for small molecules, biologics, and cosmetics. WIREs Nanomedicine and Nanobiotechnology. 3:449-462. (2011).

Modeling the Effects of Lipid Composition on Stratum Corneum Bilayers Using Molecular Dynamics Simulations

AIP Conference Proceedings

Huzil J.T., Sivaloganathan S., Kohandel M., and Foldvari M. Modeling the Effects of Lipid Composition on Stratum Corneum Bilayers Using Molecular Dynamics Simulations. AIP Conference Proceedings. 1368:175-178 (2011).

Non-Covalent Functionalization of Carbon Nanotubes with Surfactants for Pharmaceutical Applications - A Critical Mini-Review

Drug Delivery Letters

Lamprecht C., Huzil J.T., Ivanova M.V. and Foldvari M. Non-Covalent Functionalization of Carbon Nanotubes with Surfactants for Pharmaceutical Applications - A Critical Mini-Review. Drug Delivery Letters. 1:45-57. (2011).

Pharmaceutical characterization of solid and dispersed carbon nanotubes as nanoexcipients

International Journal of Nanomedicine

Ivanova M.V., Lamprecht C., Loureiro M.J., Huzil J.T., and Foldvari M. Pharmaceutical characterization of solid and dispersed carbon nanotubes as nanoexcipients. International Journal of Nanomedicine. 7:403-415. (2012).