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lyon, france
It's currently 11:03 AM here
Joined February 6, 2009
0 Recommendations
Aleksandra B.
@obyszuk
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lyon, france
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English / French / Polish
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Experience
Junior executiv
Jan 2013 - Jun 2013 (5 months, 1 day)
Audiovisual production company, working a TV cartoon series.
Film distribution coordinator
Feb 2012 - Dec 2012 (10 months, 1 day)
Coordinating the release of three indie movies in France
Education
Postgraduate education
(2 years)
MSc
(5 years)
Qualifications
TOEFL
ETS
2011
Testing my English skills
Certificate in Advanced English
University of Cambridge
2002
Testing my English skills
Publications
A novel mode of intervention with serine protease activity: targeting zymogen activation.
The Journal of Biological Chemistry
CO-AUTHOR
Abstract
Serine proteases are secreted from cells as single-chain zymogens, typically having activities orders of magnitude lower than those of the mature two-chain enzymes. Activation occurs by a conformational change initiated by cleavage of a specific peptide bond. We have derived a monoclonal antibody (mAb-112) which binds with subnanomolar affinity to pro-uPA, the zymogen form of urokinase-type plasminogen activator (uPA). We mapped the epitope of the antibody to the autolysis loop, one of
Nonproteolytic induction of catalytic activity into the single-chain form of urokinase-type plasminogen activator by dipeptides.
Biochemistry
CO-AUTHOR
Abstract
Serine proteases are initially synthesized as single-chain proenzymes with activities that are many orders of magnitude lower than those of the mature enzyme. Proteolytic cleavage of an exposed loop liberates a new amino terminus that inserts into a hydrophobic pocket and forms a stabilizing salt bridge with a ubiquitously conserved aspartate residue, resulting in a conformational change organizing the mature oxyanion hole. In a decisive 1976 work, Huber and Bode [Bode, W., and Huber, R
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